Hair-loss treatment claims, growth factors and NMN

A study of a cocktail and a delivery procedure

The cited research investigated a growth-factor cocktail containing FGF5s and NMN in androgenetic alopecia. It used a microneedling procedure to assist delivery. It was not a comparison showing that oral NMN should be used before an established hair-loss treatment.

The Japanese archive's headline implies that conventional treatment inevitably causes erectile dysfunction and that NMN is therefore preferable. Neither conclusion follows from the study described.

Microneedling and the hair follicle

The archive discusses how small punctures in the skin can influence local tissue responses and the penetration of an applied preparation. It also describes research involving Wnt-related signaling and the hair-growth cycle.

These mechanisms create a challenge for interpretation: any response may involve the procedure, the combination of ingredients, individual growth factors or their interactions. It cannot automatically be attributed to NMN.

Growth factors and NMN have different roles

FGF5s was discussed in relation to the transition from the growth phase of the hair cycle. Other growth-factor research mentioned in the archive provides background, but results from different formulations cannot be treated as identical.

NMN is a precursor used in NAD+ biosynthesis. Its participation in cellular metabolism is not evidence that an oral supplement treats androgenetic alopecia.

Comparing treatment risks requires appropriate evidence

The original article mentions sexual adverse effects associated with some medicines used for hair loss. The possibility of an adverse effect is not the same as an inevitable outcome in every patient. Treatment choices require an assessment of likely benefit, possible harm and individual circumstances.

The cited multi-component study does not establish that substituting NMN avoids those risks while retaining treatment effectiveness. It also does not justify stopping prescribed medication.

Conclusion

This archive concerns an experimental approach combining ingredients with a local delivery technique. Its findings cannot support the headline's proposed treatment sequence or a claim that GAAH supplements prevent erectile dysfunction or restore hair growth.

Cited paper: Therapeutic effects of growth factor cocktail (Cellcurin™) containing FGF5s and NMN in patients with androgenetic alopecia: A split study. The unsupported treatment recommendation in the original headline is not retained in this English edition.